Oncolytic Orf virus licenses NK cells via cDC1 to activate innate and adaptive antitumor mechanisms and extends survival in a murine model of late-stage ovarian cancer

Background Novel therapies are needed to improve outcomes for women diagnosed with ovarian cancer.Oncolytic viruses are multifunctional immunotherapeutic biologics that preferentially infect cancer cells and stimulate inflammation with the potential to generate antitumor immunity.Herein we describe Parapoxvirus ovis (Orf virus (OrfV)), an oncolytic

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A methodological approach to identify cheap and accurate indicators for biodiversity assessment: application to grazing management and two grassland bird species

In response to environmental threats, numerous indicators have been developed to assess the impact of livestock farming systems on the environment.Some of them, notably those based on management practices have been reported to have low accuracy.This paper reports the results of a study aimed at assessing whether accuracy can be increased at a reaso

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Cost-benefit analysis: the first real rule of fight club?

Competition is ubiquitous among social animals.Vying against a conspecific to achieve a particular outcome often requires one to act aggressively, but this is a costly and inherently risky behaviour.So why do we aggressively compete, or at the extreme, fight against others? Early work suggested that competitive aggression might stem from an innate

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Biodiversity of genus Orius (Hemiptera: Anthocoridae) in various climate regions and seasons of Kohgiloyeh and Boyerahmad province and evaluation of agro-ecosystem effects on their biodiversity

The members of genus Orius are known as natural enemies of many of plant pests in the world.We studied the fauna and biodiversity of the family Anthocoridae bugs in different environmental conditions of Kohgiloyeh Oral Pain Remedies And Miscellaneous and Boyrahmad province of Iran.Sampling took place in three climates and from three ecosystems (gar

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THE PRESUMPTION OF INNOCENCE AS A FUNDAMENTAL HUMAN RIGHT IN THE BRAZILIAN CONSTITUTION AND ITS APPLICATION BY THE SUPREME FEDERAL COURT

This article investigates the historical formation of the presumption of innocence and its establishment in international norms of protection of Human Rights such as the Universal Declaration and the American Convention.It also investigates the reception by Brazil of such legislation and its corollary in the Brazilian Federal Constitution of 1988.T

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